Endocrine Abstracts

In this study, we attempted to demonstrate the expression of GHSR-1a receptor and possible effects of its activation in human, rat and boar spermatozoa. For demonstration of GHSR-1a immunocytochemical, immunofluorescence and western blotting techniques were applied. The effects of receptor activation was tested in a series of in vitro incubations of spermatozoa with or without addition of ghrelin and the effects were evaluated using confocal microscopy and flow cytometr...

Background: Familial resemblance was shown for body composition and risk factors in several studies. In twin studies which are powerful tool to assess genetically mediated traits significant resemblance was found in twins reared apart. In pairs of monozygotic twins was found significant resemblance in response to positive and negative energy balance. Aim of the study was to evaluate relationship of anthropometric parameters of parents and socioeconomic characteristics of famil...

Cognitive dysfunctions, observed in the course of thyroid diseases (hyper- and hypothyroidism), have – in the recent years – been the subject of interest for many research teams. Even mild disorders of thyroid functionality are associated with hormone concentration changes which affect the general mood and cognitive functions. The efficiency of cognitive functions, which allow the man’s adaptation to environment al conditions, is determined by the activities of ...

We studied levels of T3, T4, FT3, FT4, rT3 and TSH concentrations in serum and FT3, FT4, rT3 and TSH concentrations in cerebrospinal fluid (CSF) in 10 patients with brain tumor and 20 patients with acute stroke and compared them to 7 patients in control group (further clinical evaluation in control group did not show brain lesions). All patients were euthyroid. The study was approved by loc...

Introduction: Isolated corticotropic insufficiency of hypophysis with consecutive secondary adrenal insufficiency is a very rare disease. Literature notes difficulties in proper recognition and necessity of differential diagnosis, including among others chronic fatigue syndrome. In recent years, in Poland we observe more and more frequently setting this diagnosis – only on the basis of low ACTH an cortisol concentrations, despite of proper stimulation with 250 μg<sup...

It is a well-known fact that vitamin D has an impact on many tissues of human body. Recent studies showed that vitamin D deficiency has an influence on inflamation indicators in several endocrine diseases (for example PCOS, graves disease). The aim of the study was to demonstrate correlation between 25-OH vitamin D concentration and chosen inflammation indicators (C-reactive protein and insulin) in patients with non-functioning adrenal incidentalomas. Seventy-one patients hosp...

Adrenocortical carcinoma (ACC) is a rare malignancy. Authors present three cases of even less commonly encountered manifestation of ACC. Case 1: A 39-year-old male, with decompensated hypertension, was admitted to Department of Endocrinology due to a large tumor of the left adrenal gland (65 mm) revealed in the CT of the abdomen. Non-contrast attenuation was 35HU. After performing MRI with chemical shift, tumor was classified as non-adenoma as there was no significant loss of ...

Abstract: Up to 96% of changes detected in adrenal glands are non-functioning adrenal incidentalomas. Adrenal masses are associated with increased risk of metabolic syndrome (MS). Studies demonstrate that new anthropometric parameters can be useful indicators of disturbances in glucose and lipid metabolism in various diseases. The purpose of the study was to determine antropometric parameters and its relationship with MS factors according to the criteria of the International D...

Polycystic ovary syndrome is associated with lipid and carbohydrate metabolism disorders, leading to obesity and insulin resistance. The aim of the study was to asses the correlation among anthropometric parameters, metabolic markers (lipid and carbohydrate profiles) and CRP as inflammatory indicator in women with Polycystic Ovary Syndrome. The study consists of 43 women diagnosed with Polycystic Ovary Syndrome based on 2003 Rotterdam criteria. The patients were hospitalized i...

Polycystic Ovary Syndrome increases the risk of cardiovascular diseases. To factors predisposing to cardiovascular diseases belong: hypertension, lipid and carbohydrate profiles, smoking and reduced physical activity. The aim of this study was to determine the association between selected factors predisposing to cardiovascular diseases and anthropometric parameters and CRP concentration in women with Polycystic Ovary Syndrome. The study was conducted amongst 43 women, aged 18-...